Description

(9H-Fluoren-9-Yl)Methyl Formate is a specialized organic compound belonging to the fluorenylmethyloxycarbonyl (Fmoc) family of protecting group reagents. This chemical is of critical importance in modern synthetic organic chemistry, particularly in the field of peptide synthesis, where it serves as a key intermediate for introducing the Fmoc protecting group. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in the production of peptides, oligonucleotides, and other complex biomolecules requiring sequential, orthogonal protection strategies.

Application

• Peptide Synthesis: As a precursor for generating active Fmoc-chloride or Fmoc-succinimide, used for the protection of amino groups in solid-phase and solution-phase peptide synthesis.
• Oligonucleotide Synthesis: Employed in the preparation of protected nucleosides and nucleotides, facilitating the stepwise construction of DNA and RNA strands.
• Protecting Group Chemistry: A fundamental reagent for introducing the base-labile Fmoc protecting group onto amines, alcohols, and thiols in complex multi-step organic syntheses.
• Pharmaceutical Intermediates: Serves as a key building block in the research and development of active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Used in the preparation of linkers and reagents for labeling proteins, antibodies, and other biomolecules.
• Material Science Research: Applied in the synthesis of functionalized polymers and dendrimers with precise molecular architectures.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methyl Formate
CAS No.	1023867-12-0
Molecular Formula	C15H12O2
Molecular Weight	224.26 g/mol
Synonyms	Fmoc-Formate; 9-Fluorenylmethyl Formate; (9-Fluorenylmethoxy)formaldehyde; Formic Acid 9H-Fluoren-9-ylmethyl Ester; N-(9-Fluorenylmethoxycarbonyl) Formate; Fmoc-O-Formate; 9-Fluorenylmethyloxycarbonyl Formate; (9-Fluorenylmethyl) Formate
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methyl Formate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and synthesis applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.