Description

5,6,7,8-Tetrahydro-[1,8]Naphthyridine-3-Carboxylic Acid is a high-purity, heterocyclic carboxylic acid building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel pharmaceutical agents, particularly in medicinal chemistry research. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of complex molecules for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly for central nervous system (CNS) and anti-infective targets.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization stages for constructing complex heterocyclic scaffolds with potential biological activity.
• Chemical Synthesis: Serves as a versatile precursor for amide coupling, esterification, and other derivatization reactions to create libraries of compounds for screening.
• Ligand and Catalyst Development: The naphthyridine core can be utilized in the design of chelating ligands for metal catalysts or in materials science applications.
• Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	5,6,7,8-Tetrahydro-[1,8]Naphthyridine-3-Carboxylic Acid
CAS No.	1023813-84-4
Molecular Formula	C9H10N2O2
Molecular Weight	178.19 g/mol
Synonyms	3-Carboxy-5,6,7,8-tetrahydro-1,8-naphthyridine; 5,6,7,8-Tetrahydro-1,8-naphthyridine-3-carboxylic acid; THNCA; 1,8-Naphthyridine-3-carboxylic acid, 5,6,7,8-tetrahydro-; 1023813-84-4; Tetrahydro[1,8]naphthyridine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydro-[1,8]Naphthyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.