Description

tert-Butyl 1-Oxa-4,9-Diazaspiro[5.5]Undecane-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic amine class, valued for its role as a key building block in modern drug discovery. This compound is essential for the synthesis of complex molecules, offering a rigid, three-dimensional scaffold that can significantly influence the biological activity and pharmacokinetic properties of final active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical companies engaged in developing therapeutics for central nervous system (CNS) disorders, oncology, and other areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its spirocyclic structure.
• API Development: Incorporated into the core structure of potential Active Pharmaceutical Ingredients (APIs) for enhanced metabolic stability and binding affinity.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	tert-Butyl 1-Oxa-4,9-Diazaspiro[5.5]Undecane-4-Carboxylate
CAS No.	1023595-11-0
Molecular Formula	C13H24N2O3
Molecular Weight	256.34 g/mol
Synonyms	1-Oxa-4,9-diazaspiro[5.5]undecane-4-carboxylic acid, 1,1-dimethylethyl ester; 4-(tert-Butoxycarbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane; tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate; 1-Oxa-4,9-diazaspiro[5.5]undecane-4-carboxylic acid tert-butyl ester; Boc-1-oxa-4,9-diazaspiro[5.5]undecane; BOC-ODAU; 1023595-11-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Oxa-4,9-Diazaspiro[5.5]Undecane-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.