Description

4-(Boc-Amino)-1-(2-Aminophenyl)-Piperidine is a high-purity, bifunctional piperidine derivative that serves as a critical advanced intermediate in modern organic synthesis. Its value lies in the orthogonal protection of its amine groups, enabling precise, sequential functionalization for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used to incorporate constrained piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and medicinal chemistry.
• Agrochemical Development: Employed in the research and synthesis of new generation herbicides and pesticides.
• Chemical Biology Probes: Useful for constructing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis projects.

Basic Information

Product Name	4-(Boc-Amino)-1-(2-Aminophenyl)-Piperidine
CAS No.	1023594-61-7
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	1-(2-Aminophenyl)-4-[(tert-butoxycarbonyl)amino]piperidine; tert-Butyl N-[1-(2-aminophenyl)piperidin-4-yl]carbamate; 4-[(tert-Butoxycarbonyl)amino]-1-(2-aminophenyl)piperidine; 4-(Boc-amino)-1-(2-aminophenyl)piperidine; 1-(2-Aminophenyl)-4-(Boc-amino)piperidine; N-Boc-4-amino-1-(2-aminophenyl)piperidine; 1023594-61-7
EINECS	Contact for details

Quality Control

Our 4-(Boc-Amino)-1-(2-Aminophenyl)-Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and current industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.