Description

tert-Butyl 2,9-Diazaspiro[5.5]undecane-2-carboxylate hydrochloride is a high-purity, protected spirocyclic diamine building block essential for advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, offering a rigid, three-dimensional scaffold that is highly valuable in modern drug discovery. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel therapeutic candidates targeting central nervous system disorders, metabolic diseases, and other challenging therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic structure.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional degrader molecules.
• Chemical Biology Probes: Incorporated into tool compounds for target identification and validation studies within biological systems.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of complex drug substances.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and new methodology development.

Basic Information

Product Name	tert-Butyl 2,9-Diazaspiro[5.5]undecane-2-carboxylate hydrochloride
CAS No.	1023301-88-3
Molecular Formula	C14H27N2O2 • HCl
Molecular Weight	300.84 g/mol (as hydrochloride salt)
Synonyms	2,9-Diazaspiro[5.5]undecane-2-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride; tert-Butyl 2,9-diazaspiro[5.5]undecane-2-carboxylate HCl; 2,9-Diazaspiro[5.5]undecane-2-carboxylic acid tert-butyl ester hydrochloride; 2-tert-Butoxycarbonyl-2,9-diazaspiro[5.5]undecane hydrochloride; Boc-2,9-diazaspiro[5.5]undecane hydrochloride; 1-Boc-2,9-diazaspiro[5.5]undecane hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of tert-Butyl 2,9-Diazaspiro[5.5]undecane-2-carboxylate hydrochloride is manufactured under controlled conditions and subjected to comprehensive analytical characterization. We provide full traceability and detailed Certificates of Analysis (COA) upon request, which include data for identity, purity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.