Description

tert-Butyl 3-(Trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate is a high-value, advanced pharmaceutical intermediate featuring a fused pyrazolopyridine core with a strategically positioned trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for constructing novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of new chemical entities (NCEs), particularly for applications in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• CNS Drug Development: The pyrazolopyridine structure is commonly explored for developing compounds targeting neurological disorders.
• Kinase Inhibitor Synthesis: Acts as a precursor in the creation of potential kinase inhibitors for oncology research.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Scale-up: A critical starting material for contract manufacturing organizations (CMOs) providing custom synthesis services from milligram to kilogram scale.

Basic Information

Product Name	tert-Butyl 3-(Trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
CAS No.	1022931-73-2
Molecular Formula	C12H14F3N3O2
Molecular Weight	289.25 g/mol
Synonyms	5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1,4,6,7-tetrahydro-3-(trifluoromethyl)-, 1,1-dimethylethyl ester; tert-Butyl 3-(trifluoromethyl)-4,6,7,8-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate; 1,1-Dimethylethyl 1,4,6,7-tetrahydro-3-(trifluoromethyl)-5H-pyrazolo[4,3-c]pyridine-5-carboxylate; 3-(Trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester; Boc-protected 3-trifluoromethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 3-(Trifluoromethyl)-1,4,6,7-tetrahydro-5H-Pyrazolo[4,3-C]Pyridine-5-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical specifications. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.