Description

3H-Imidazo[4,5-B]Pyridine-3-Carboxylicacid,6-Bromo-,1,1-Dimethylethylester is a high-purity, advanced pharmaceutical intermediate characterized by its imidazopyridine core and bromo-substituent. This compound is a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of small-molecule therapeutics, particularly for oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) with potential kinase inhibitory or receptor-modulating activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the creation of focused compound libraries for high-throughput screening.
• Oncology Drug Discovery: Used in the development of targeted cancer therapies, leveraging the bromo group for further functionalization via cross-coupling reactions.
• CNS Drug Development: Employed in constructing molecules designed to cross the blood-brain barrier for treating neurological conditions.
• Chemical Biology Probes: Acts as a starting material for creating tool compounds to study specific biological pathways and protein functions.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	3H-Imidazo[4,5-B]Pyridine-3-Carboxylicacid,6-Bromo-,1,1-Dimethylethylester
CAS No.	1021919-30-1
Molecular Formula	C13H14BrN3O2
Molecular Weight	324.18 g/mol
Synonyms	6-Bromo-3H-imidazo[4,5-b]pyridine-3-carboxylic acid tert-butyl ester; tert-Butyl 6-bromo-3H-imidazo[4,5-b]pyridine-3-carboxylate; 6-Bromo-3-(tert-butoxycarbonyl)-3H-imidazo[4,5-b]pyridine; 1,1-Dimethylethyl 6-bromo-3H-imidazo[4,5-b]pyridine-3-carboxylate; 6-Bromo-imidazo[4,5-b]pyridine-3-carboxylic acid tert-butyl ester; 1021919-30-1; tert-Butyl 6-bromoimidazo[4,5-b]pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our 3H-Imidazo[4,5-B]Pyridine-3-Carboxylicacid,6-Bromo-,1,1-Dimethylethylester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material suitability for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.