Description

2-(tert-Butoxycarbonylamino)-4-Chloronicotinic Acid CAS NO 1021339-32-1 is a high-purity, protected nicotinic acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex heterocyclic molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that utilize nicotinic acid scaffolds.
• Chemical Biology & Proteomics: Serves as a precursor for activity-based probes and other tools used in target identification and validation studies.
• Peptidomimetics & Conjugate Chemistry: The carboxylic acid and protected amine functionalities allow for incorporation into peptide backbones or conjugation to other molecular entities.
• Material Science Precursor: Potential use in synthesizing functionalized ligands for metal-organic frameworks (MOFs) or other advanced materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-(tert-Butoxycarbonylamino)-4-Chloronicotinic Acid
CAS No.	1021339-32-1
Molecular Formula	C11H13ClN2O4
Molecular Weight	272.69 g/mol
Synonyms	4-Chloro-2-[(tert-butoxycarbonyl)amino]nicotinic Acid; 2-[(tert-Butoxycarbonyl)amino]-4-chloropyridine-3-carboxylic Acid; 2-(Boc-amino)-4-chloronicotinic Acid; Boc-4-Cl-Nicotinic Acid; 4-Chloro-2-((tert-butoxycarbonyl)amino)nicotinic Acid; 2-(N-Boc-amino)-4-chloronicotinic Acid; 3-Carboxy-4-chloro-2-pyridinylcarbamic Acid 1,1-Dimethylethyl Ester
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonylamino)-4-Chloronicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP-compliant production for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.