Description

2-Chloro-4-Pivalamidonicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific chloronicotinic acid and pivalamide functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, especially within the fields of oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex heterocyclic molecules and studying structure-activity relationships (SAR).
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation herbicides and plant growth regulators.
• Material Science: Investigated for the preparation of specialized ligands and functional monomers for advanced polymeric materials.

Basic Information

Product Name	2-Chloro-4-Pivalamidonicotinic Acid
CAS No.	1021339-24-1
Molecular Formula	C11H11ClN2O3
Molecular Weight	254.67 g/mol
Synonyms	4-(2,2-Dimethylpropanamido)-2-chloropyridine-5-carboxylic Acid; 2-Chloro-4-(pivaloylamino)nicotinic Acid; 2-Chloro-4-(2,2-dimethylpropanamido)nicotinic Acid; 5-Carboxy-2-chloro-4-pivalamidopyridine; Piv-Cit; 1021339-24-1 (CAS); 2-Chloro-4-pivalamidonicotinic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Pivalamidonicotinic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.