Description

5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile is a high-value, heterocyclic organic building block characterized by its fused pyrrolopyridine core and reactive nitrile and chloro substituents. This compound matters as a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used as a building block for creating novel herbicides, fungicides, and insecticides with specific modes of action.
• Material Science Research: Serves as a precursor for the development of organic electronic materials and advanced polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring complex heterocyclic frameworks.
• Academic & Institutional Research: Employed in universities and research institutes for methodological studies and novel compound library generation.

Basic Information

Product Name	5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile
CAS No.	1021339-16-1
Molecular Formula	C8H4ClN3
Molecular Weight	177.59 g/mol
Synonyms	5-Chloro-4-cyano-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile; 4-Cyano-5-chloro-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 5-chloro-; 5-Chloro-4-cyanopyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.