Description

tert-Butyl 4-(3-Hydroxybenzylidene)Piperidine-1-Carboxylate is a high-purity, protected piperidine derivative featuring a benzylidene moiety, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in enabling the controlled synthesis of complex pharmacophores, offering researchers a versatile building block for constructing novel molecular architectures. This compound is essential for pharmaceutical R&D chemists and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Chemical Biology Probe Development: Serves as a starting material for creating labeled or tagged molecules used to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 4-(3-Hydroxybenzylidene)Piperidine-1-Carboxylate
CAS No.	1020329-87-6
Molecular Formula	C17H23NO3
Molecular Weight	289.37 g/mol
Synonyms	1-Boc-4-[(3-hydroxyphenyl)methylene]piperidine; 4-(3-Hydroxybenzylidene)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-[(3-hydroxyphenyl)methylidene]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(3-hydroxyphenyl)methylene]piperidine; 4-(3-Hydroxybenzylidene)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; Boc-4-(3-hydroxybenzylidene)piperidine; 1020329-87-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Hydroxybenzylidene)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.