Description

Ethyl (2-Bromo-5-Fluorobenzoyl)Acetate is a high-purity fluorinated and brominated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional halogenated structure, which provides versatile reactivity for constructing complex molecular architectures. This intermediate is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncological pathways.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and bromine atoms for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals with unique optical or electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) due to the reactive bromine atom, enabling carbon-carbon bond formation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	Ethyl (2-Bromo-5-Fluorobenzoyl)Acetate
CAS No.	1020058-49-4
Molecular Formula	C11H10BrFO3
Molecular Weight	289.10 g/mol
Synonyms	Ethyl 2-(2-Bromo-5-fluorobenzoyl)acetate; Acetic acid, 2-(2-bromo-5-fluorobenzoyl)-, ethyl ester; 2-Bromo-5-fluorobenzoylacetic acid ethyl ester; Ethyl (2-bromo-5-fluorobenzoyl)ethanoate; (2-Bromo-5-fluorophenyl)(2-ethoxy-2-oxoethyl)methanone; Ethyl 3-oxo-3-(2-bromo-5-fluorophenyl)propanoate
EINECS	Contact for details

Quality Control

Our production of Ethyl (2-Bromo-5-Fluorobenzoyl)Acetate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.