Description

8-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-3(2H)-One is a high-value, heterocyclic organic compound featuring a fused triazolopyridine core with a strategically positioned trifluoromethyl group. This structure is of significant interest in advanced pharmaceutical and agrochemical research, where it serves as a critical building block for developing novel active ingredients. Its primary utility lies in medicinal chemistry for the synthesis of potential drug candidates, particularly targeting central nervous system (CNS) disorders and other therapeutic areas. The compound is also leveraged in material science and as a key intermediate for specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in CNS-targeted therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the triazolopyridine scaffold.
• Material Science: Serves as a precursor for the development of advanced organic electronic materials and functional polymers.
• Chemical Biology: Employed as a molecular probe or building block in the study of biological pathways and target validation.
• Fine Chemical Synthesis: An important intermediate for creating complex, fluorinated heterocyclic compounds in custom synthesis projects.

Basic Information

Product Name	8-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-3(2H)-One
CAS No.	1020039-20-6
Molecular Formula	C7H4F3N3O
Molecular Weight	203.12 g/mol
Synonyms	8-(Trifluoromethyl)-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one; 8-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one; 1020039-20-6; 8-Trifluoromethyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; 8-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridin-3-ol (tautomer); Triazolopyridine trifluoromethyl derivative
EINECS	Contact for details

Quality Control

Our production of 8-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-3(2H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced under GMP-like conditions where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.