Description

6-[(2,2,2-Trifluoroethyl)Amino]Pyridine-3-Carboxylic Acid is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its primary commercial value lies in its role as a versatile intermediate for constructing complex molecules with enhanced biological activity and metabolic stability. This compound is essential for research and development teams in the pharmaceutical and agrochemical industries, particularly those focused on discovering new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where the trifluoromethyl group imparts improved lipophilicity and target binding.
• Ligand & Catalyst Development: Serves as a functionalized pyridine ligand for constructing metal-organic frameworks (MOFs) and transition metal catalysts.
• Material Science: Building block for specialty polymers and advanced organic electronic materials requiring specific fluorine-containing motifs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up services.

Basic Information

Product Name	6-[(2,2,2-Trifluoroethyl)Amino]Pyridine-3-Carboxylic Acid
CAS No.	1019388-10-3
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	2,2,2-Trifluoro-N-(5-carboxypyridin-2-yl)ethanamine; 6-[(2,2,2-Trifluoroethyl)amino]nicotinic acid; 2-Amino-5-carboxypyridine trifluoroethyl derivative; 5-Carboxy-2-[(2,2,2-trifluoroethyl)amino]pyridine; 1019388-10-3; 6-(Trifluoroethylamino)pyridine-3-carboxylic acid; 2-[(2,2,2-Trifluoroethyl)amino]isonicotinic acid (related isomer)
EINECS	Contact for details

Quality Control

Our production of 6-[(2,2,2-Trifluoroethyl)Amino]Pyridine-3-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your internal quality standards and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.