Description

Imidazo[1,2-A]Pyridine-2-Carboxylic Acid, 8-(Trifluoromethyl)- is a high-value heterocyclic building block characterized by its fused imidazole-pyridine core and a strategically positioned trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for creating novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of advanced intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective targets.
• Medicinal Chemistry Scaffold: Serves as a privileged structure in hit-to-lead and lead optimization campaigns due to its favorable physicochemical properties imparted by the trifluoromethyl group.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the imidazopyridine core can contribute to biological activity.
• Material Science Precursor: Employed in the research of organic electronic materials, such as ligands for catalysts or components in organic light-emitting diodes (OLEDs).
• Chemical Biology Probe: Utilized as a building block for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the pharmaceutical and biotechnology industries.

Basic Information

Product Name	Imidazo[1,2-A]Pyridine-2-Carboxylic Acid, 8-(Trifluoromethyl)-
CAS No.	1018828-72-2
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.15 g/mol
Synonyms	8-(Trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid; 8-Trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid; Imidazo[1,2-a]pyridine-2-carboxylic acid, 8-(trifluoromethyl)-; 1018828-72-2; 8-CF3-Imidazo[1,2-a]pyridine-2-carboxylic acid; AI3-71497; ZINC000103223535; SCHEMBL18806427
EINECS	Contact for details

Quality Control

Our Imidazo[1,2-A]Pyridine-2-Carboxylic Acid, 8-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.