Description

5-(4-Chlorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities. The precise functionalization of the nicotinic acid core makes it a valuable building block for medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Agrochemical Development: Used in research for creating new active ingredients for crop protection products, leveraging its halogenated aromatic system.
• Chemical Synthesis Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Organic Electronic Materials Research: Investigated as a potential building block for specialty polymers and small molecules in material science applications.

Basic Information

Product Name	5-(4-Chlorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic Acid
CAS No.	1018782-82-5
Molecular Formula	C14H9ClF3NO3
Molecular Weight	331.67 g/mol
Synonyms	5-(4-Chlorophenyl)-6-[(2,2,2-trifluoroethoxy)]pyridine-3-carboxylic acid; 6-(2,2,2-Trifluoroethoxy)-5-(4-chlorophenyl)nicotinic acid; 3-Pyridinecarboxylic acid, 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-; 1018782-82-5; 5-(p-Chlorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid
EINECS	Contact for details

Quality Control

Our 5-(4-Chlorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.