Description

3-(Difluoromethyl)Picolinaldehyde is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a difluoromethyl group and an aldehyde functionality, makes it indispensable for creating novel compounds with tailored properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Ligand & Catalyst Development: Serves as a versatile starting material for constructing complex ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of specialty polymers and advanced organic electronic materials due to its electron-withdrawing characteristics.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(Difluoromethyl)Picolinaldehyde
CAS No.	1018678-51-7
Molecular Formula	C7H5F2NO
Molecular Weight	157.12 g/mol
Synonyms	3-(Difluoromethyl)pyridine-2-carboxaldehyde; 2-Pyridinecarboxaldehyde, 3-(difluoromethyl)-; 3-(Difluoromethyl)-2-pyridinecarboxaldehyde; 3-(Difluoromethyl)picolinaldehyde; 3-Difluoromethylpicolinaldehyde; 3-Difluoromethyl-2-pyridinecarboxaldehyde; 3-(Difluoromethyl)-2-formylpyridine; Picolinaldehyde, 3-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Picolinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.