Description

4-Amino-2-(Trifluoromethyl)Nicotinic Acid is a high-value trifluoromethyl-substituted nicotinic acid derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring both an amino group and a trifluoromethyl group on the pyridine ring, makes it an essential intermediate for creating compounds with enhanced biological activity and metabolic stability. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological efficacy.
• Chemical Research & Development: Serves as a versatile building block in organic synthesis for constructing complex heterocyclic compounds and fluorinated analogs in academic and industrial labs.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals, ligands for catalysis, and advanced materials requiring specific fluorine-containing motifs.

Basic Information

Product Name	4-Amino-2-(Trifluoromethyl)Nicotinic Acid
CAS No.	1018678-42-6
Molecular Formula	C7H5F3N2O2
Molecular Weight	206.12 g/mol
Synonyms	2-(Trifluoromethyl)-4-aminonicotinic Acid; 4-Amino-2-trifluoromethylpyridine-3-carboxylic Acid; 3-Pyridinecarboxylic acid, 4-amino-2-(trifluoromethyl)-; 4-Amino-2-(trifluoromethyl)-3-pyridinecarboxylic acid; 1018678-42-6; 4-Amino-2-trifluoromethylnicotinic acid
EINECS	Contact for details

Quality Control

Our 4-Amino-2-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.