Description

4-Chloro-2-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-functional chemical intermediate characterized by its unique halogenated and trifluoromethylated pyridine structure. This compound matters for its critical role in facilitating complex molecular transformations, particularly in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with enhanced biological activity and physical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers requiring specific halogenated aromatic components.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services for clients in life sciences.

Basic Information

Product Name	4-Chloro-2-(Trifluoromethyl)Nicotinic Acid
CAS No.	1018678-39-1
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	4-Chloro-2-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 4-chloro-2-(trifluoromethyl)-; 4-Chloro-2-trifluoromethylnicotinic acid; 2-Trifluoromethyl-4-chloronicotinic acid; 4-Chloro-2-(trifluoromethyl)-3-pyridinecarboxylic acid; 1018678-39-1; Nicotinic acid, 4-chloro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Trifluoromethyl)Nicotinic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.