Description

{[4-(Difluoromethyl)-2-Ethyl-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is valued for its unique heterocyclic pyrazolopyridine core functionalized with a difluoromethyl group and a thioacetic acid side chain, offering versatile reactivity for medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapies, including kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly in oncology and anti-inflammatory therapeutic areas.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor for compounds targeting specific kinase enzymes involved in cell signaling pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its modifiable functional groups.
• Bioconjugation & Probe Synthesis: The thioacetic acid moiety can be utilized for conjugation chemistry, enabling the creation of biochemical probes or antibody-drug conjugates (ADCs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Employed in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery.

Basic Information

Product Name	{[4-(Difluoromethyl)-2-Ethyl-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid
CAS No.	1018166-37-4
Molecular Formula	C11H11F2N3O2S
Molecular Weight	287.28 g/mol
Synonyms	2-{[4-(Difluoromethyl)-2-ethyl-2H-pyrazolo[3,4-b]pyridin-6-yl]sulfanyl}acetic acid; 2-({4-(Difluoromethyl)-2-ethyl-2H-pyrazolo[3,4-b]pyridin-6-yl}thio)acetic acid; (4-Difluoromethyl-2-ethyl-2H-pyrazolo[3,4-b]pyridin-6-ylthio)acetic acid; 1018166-37-4; Acetic acid, 2-[[4-(difluoromethyl)-2-ethyl-2H-pyrazolo[3,4-b]pyridin-6-yl]thio]-; 6-Mercapto-4-(difluoromethyl)-2-ethyl-2H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester derivative
EINECS	Contact for details

Quality Control

Our {[4-(Difluoromethyl)-2-Ethyl-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade materials for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.