Description

{[4-(Difluoromethyl)-2-Methyl-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid is a high-value, heterocyclic building block featuring a pyrazolopyridine core functionalized with a difluoromethyl group and a thioacetic acid side chain. This compound matters as a critical intermediate in modern pharmaceutical research, enabling the synthesis of novel drug candidates with enhanced metabolic stability and binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drug candidates, particularly in kinase inhibitor programs.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology Probe Development: Serves as a core scaffold for creating tool compounds to study biological pathways.
• Medicinal Chemistry SAR Studies: The difluoromethyl and thioacetic acid moieties are valuable for structure-activity relationship (SAR) optimization.
• Process Chemistry & Scale-Up: Intermediate for developing robust and scalable synthetic routes to final active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	{[4-(Difluoromethyl)-2-Methyl-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid
CAS No.	1018166-29-4
Molecular Formula	C11H9F2N3O2S
Molecular Weight	285.27 g/mol
Synonyms	2-({4-(Difluoromethyl)-2-methyl-2H-pyrazolo[3,4-b]pyridin-6-yl}thio)acetic acid; {[4-(Difluoromethyl)-2-methyl-2H-pyrazolo[3,4-b]pyridin-6-yl]sulfanyl}acetic acid; 6-[(Carboxymethyl)thio]-4-(difluoromethyl)-2-methyl-2H-pyrazolo[3,4-b]pyridine; 1018166-29-4; Pyrazolo[3,4-b]pyridine-6-thioacetic acid, 4-(difluoromethyl)-2-methyl-; CAS 1018166-29-4
EINECS	Contact for details

Quality Control

Our {[4-(Difluoromethyl)-2-Methyl-2H-Pyrazolo[3,4-B]Pyridin-6-Yl]Thio}Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.