Description

2-[3-Cyclopropyl-6-Isopropyl-4-(Trifluoromethyl)Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid is a high-value, structurally complex pyrazolopyridine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in enabling the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and cyclopropyl motifs are key for modulating biological activity and physicochemical properties. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate new small molecule therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, antiviral, and anti-inflammatory research pipelines.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study specific biological pathways and protein targets.
• Material Science Research: Investigated as a precursor for specialty polymers or organic electronic materials due to its conjugated heterocyclic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise molecular architecture.

Basic Information

Product Name	2-[3-Cyclopropyl-6-Isopropyl-4-(Trifluoromethyl)Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid
CAS No.	1018144-00-7
Molecular Formula	C15H16F3N3O2
Molecular Weight	327.30 g/mol
Synonyms	1H-Pyrazolo[3,4-b]pyridine-1-acetic acid, 3-cyclopropyl-4-(trifluoromethyl)-6-(1-methylethyl)-; 2-(3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid; 3-Cyclopropyl-6-isopropyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine-1-acetic acid; CAS 1018144-00-7; Pyrazolopyridine acetic acid derivative; Trifluoromethyl pyrazolopyridine intermediate
EINECS	Contact for details

Quality Control

Every batch of 2-[3-Cyclopropyl-6-Isopropyl-4-(Trifluoromethyl)Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and process development. Certificates of Analysis (COA) detailing all specification results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is a strong acid and should be stored separately from bases and reactive materials. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.