Description

1-(2,2-Difluoroethyl)-3,6-Dimethyl-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is valued for its role as a key building block in medicinal chemistry, particularly for introducing the difluoroethyl-pyrazolopyridine scaffold into target molecules. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Kinase Inhibitor Development: Serves as a core scaffold in the research and synthesis of potential kinase inhibitor candidates.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for exploring new heterocyclic chemistry and bioactivity.

Basic Information

Product Name	1-(2,2-Difluoroethyl)-3,6-Dimethyl-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid
CAS No.	1018142-54-5
Molecular Formula	C12H11F2N3O2
Molecular Weight	267.24 g/mol
Synonyms	1-(2,2-Difluoroethyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 3,6-Dimethyl-1-(2,2-difluoroethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 1-(2,2-difluoroethyl)-3,6-dihydro-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-; Difluoroethyl Dimethyl Pyrazolopyridine Carboxylic Acid; CAS 1018142-54-5
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluoroethyl)-3,6-Dimethyl-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.