Description

6-Cyclopropyl-1-(2,2-Difluoroethyl)-3-Methyl-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid CAS NO 1018142-22-7 is a high-purity, functionalized pyrazolopyridine derivative designed for advanced pharmaceutical research and development. This compound serves as a critical pharmaceutical intermediate or building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies. It is essential for medicinal chemists and R&D teams in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new drug candidates with specific biological activity.

Application

This specialized chemical intermediate is primarily utilized in sophisticated organic synthesis pathways. Its key applications include:

• Pharmaceutical Intermediate: Serving as a core scaffold or precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted small-molecule therapeutics.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization studies to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• API Development: Acting as a key building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) under GMP or non-GMP conditions.
• Biochemical Tool Compound: Potential use in developing probes for biological target validation and assay development in early-stage drug discovery.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, complex organic molecules.

Basic Information

Product Name	6-Cyclopropyl-1-(2,2-Difluoroethyl)-3-Methyl-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid
CAS No.	1018142-22-7
Molecular Formula	C15H15F2N3O2
Molecular Weight	307.30 g/mol
Synonyms	6-Cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 6-cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-; 1018142-22-7; Difluoroethyl Cyclopropyl Methyl Pyrazolopyridine Carboxylic Acid; Pyrazolo[3,4-b]pyridine-4-carboxylic acid derivative; 6-Cyclopropyl-3-methyl-1-(2,2-difluoroethyl)pyrazolo[3,4-b]pyridine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to verify identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. For advanced applications, we can support development under quality frameworks appropriate for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.