Description

6-Chloro-4-(difluoromethyl)-2-propyl-2H-pyrazolo[3,4-b]pyridine is a high-purity, advanced pharmaceutical intermediate and heterocyclic building block. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by pharmaceutical R&D organizations, agrochemical innovators, and fine chemical manufacturers engaged in developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides due to its unique pyrazolopyridine core.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds in biochemical research.
• Material Science: Potential precursor for the synthesis of specialty chemicals and functional materials with specific electronic properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and fluorine chemistry.

Basic Information

Product Name	6-Chloro-4-(difluoromethyl)-2-propyl-2H-pyrazolo[3,4-b]pyridine
CAS No.	1018128-29-4
Molecular Formula	C11H10ClF2N3
Molecular Weight	257.67 g/mol
Synonyms	6-Chloro-4-(difluoromethyl)-2-propyl-1H-pyrazolo[3,4-b]pyridine; 2H-Pyrazolo[3,4-b]pyridine, 6-chloro-4-(difluoromethyl)-2-propyl-; 1018128-29-4; 6-Chloro-4-difluoromethyl-2-propyl-2H-pyrazolo[3,4-b]pyridine; 4-(Difluoromethyl)-6-chloro-2-propyl-2H-pyrazolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 6-Chloro-4-(difluoromethyl)-2-propyl-2H-pyrazolo[3,4-b]pyridine adheres to stringent quality management systems. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our commitment to cGMP principles and ISO-aligned processes guarantees a reliable supply of this high-value intermediate for critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong oxidizers and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.