Description

6-Chloro-2-Isobutyl-4-(Trifluoromethyl)-2H-Pyrazolo[3,4-B]Pyridine is a high-value, heterocyclic organic compound featuring a pyrazolopyridine core substituted with chloro, isobutyl, and trifluoromethyl groups. This unique structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for medicinal chemistry research. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients. The compound's properties are leveraged to develop molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl group can impart improved efficacy and environmental profile.
• Medicinal Chemistry: Serves as a privileged scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology: Employed as a probe or tool compound to study biological pathways and enzyme interactions.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functional materials requiring specific fluorinated heterocyclic structures.

Basic Information

Product Name	6-Chloro-2-Isobutyl-4-(Trifluoromethyl)-2H-Pyrazolo[3,4-B]Pyridine
CAS No.	1018127-90-6
Molecular Formula	C12H11ClF3N3
Molecular Weight	289.68 g/mol
Synonyms	6-Chloro-2-isobutyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridine; 2H-Pyrazolo[3,4-b]pyridine, 6-chloro-2-(2-methylpropyl)-4-(trifluoromethyl)-; 6-Chloro-2-(2-methylpropyl)-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridine; 1018127-90-6; 6-Chloro-2-isobutyl-4-trifluoromethyl-2H-pyrazolo[3,4-b]pyridine; 6-Chloro-2-isobutyl-4-(trifluoromethyl)pyrazolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Isobutyl-4-(Trifluoromethyl)-2H-Pyrazolo[3,4-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time matches reference standard
Identification (IR)	Spectrum conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.