Description

3-Methyl-2-Propyl-4-(Trifluoromethyl)-2,7-Dihydro-6H-Pyrazolo[3,4-B]Pyridin-6-One is a high-value, heterocyclic organic compound featuring a fused pyrazolopyridine core with a strategically positioned trifluoromethyl group. This molecular architecture makes it a critical advanced pharmaceutical intermediate for the development of novel active ingredients. It is primarily sought after by research organizations and pharmaceutical manufacturers engaged in medicinal chemistry, particularly for programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those requiring the bioisosteric and metabolic stability properties imparted by the trifluoromethyl group.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• CNS Drug Development: Applied in the research and synthesis of potential therapeutics for neurological conditions, leveraging the pyrazolopyridine scaffold's relevance in neuropharmacology.
• Kinase Inhibitor Synthesis: Functions as a core heterocycle in the design and production of small molecule kinase inhibitors for oncology and anti-inflammatory applications.
• Agrochemical Research: May be utilized in the discovery of new active ingredients for crop protection, where fluorinated heterocycles are increasingly important.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	3-Methyl-2-Propyl-4-(Trifluoromethyl)-2,7-Dihydro-6H-Pyrazolo[3,4-B]Pyridin-6-One
CAS No.	1018127-59-7
Molecular Formula	C12H12F3N3O
Molecular Weight	271.24 g/mol
Synonyms	3-Methyl-2-propyl-4-(trifluoromethyl)-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one; 6H-Pyrazolo[3,4-b]pyridin-6-one, 2,7-dihydro-3-methyl-2-propyl-4-(trifluoromethyl)-; 3-Methyl-2-propyl-4-trifluoromethyl-2,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one; CAS 1018127-59-7; Pyrazolopyridinone derivative (trifluoromethyl); TFM-Pyrazolopyridinone intermediate
EINECS	Contact for details

Quality Control

Our production of 3-Methyl-2-Propyl-4-(Trifluoromethyl)-2,7-Dihydro-6H-Pyrazolo[3,4-B]Pyridin-6-One adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques like HPLC, GC, NMR, and MS to ensure high chemical purity and structural integrity, suitable for demanding research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and kept away from moisture. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.