Description

6-Isopropyl-1-(4-Methoxyphenyl)-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially in oncology and anti-inflammatory research.
• Drug Discovery Scaffold: Serves as a core structural element for medicinal chemists to develop new chemical entities (NCEs) with optimized biological activity.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Biochemical Research: Investigated for its potential as a modulator or inhibitor in various enzymatic and receptor-based assay systems.
• Custom Synthesis: A starting point for the custom synthesis of derivatives and analogs for client-specific research programs.

Basic Information

Product Name	6-Isopropyl-1-(4-Methoxyphenyl)-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid
CAS No.	1018127-49-5
Molecular Formula	C20H21N3O3
Molecular Weight	351.40 g/mol
Synonyms	1-(4-Methoxyphenyl)-6-(propan-2-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 6-Isopropyl-1-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 6-(1-methylethyl)-1-(4-methoxyphenyl)-3-methyl-; Pyrazolopyridine carboxylic acid derivative; CAS 1018127-49-5
EINECS	Contact for details

Quality Control

Our 6-Isopropyl-1-(4-Methoxyphenyl)-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product should be kept under an inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.