Description

Methyl 6-Cyclopropyl-1-Isopropyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS number 1018125-77-3. This compound is a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), offering significant value in modern drug discovery and development pipelines. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly in oncology and antiviral research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• API Development: Serves as a core structural unit in the manufacturing process of final active pharmaceutical ingredients.
• Contract Synthesis: Supplied to CDMOs for custom synthesis and scale-up projects under cGMP conditions.
• Biochemical Research: Employed in the development of enzyme inhibitors and other biologically active molecules.

Basic Information

Product Name	Methyl 6-Cyclopropyl-1-Isopropyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylate
CAS No.	1018125-77-3
Molecular Formula	C14H17N3O2
Molecular Weight	259.31 g/mol
Synonyms	Methyl 6-cyclopropyl-1-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 6-cyclopropyl-1-(1-methylethyl)-, methyl ester; 6-Cyclopropyl-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid methyl ester; 1018125-77-3; Methyl 6-cyclopropyl-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 6-Cyclopropyl-1-Isopropyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support development and commercial projects with material suitable for research use through to cGMP-grade supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.