Description

[1-(2,2-Difluoroethyl)-3-Methyl-6-Oxo-4-(Trifluoromethyl)-1,6-Dihydro-7H-Pyrazolo[3,4-B]Pyridin-7-Yl]Acetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating multiple fluorine atoms. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly in oncology and antiviral drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel small-molecule drugs, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to improve drug candidate properties.
• Oncology Drug Development: Serves as a core scaffold in the synthesis of potential anti-cancer agents due to its privileged pyrazolopyridine structure.
• Antiviral Agent Synthesis: Employed in the research and production of antiviral compounds, leveraging the trifluoromethyl group's role in enhancing binding affinity.
• Chemical Biology Probes: Utilized to create specialized molecular probes for studying enzyme function and cellular pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical R&D pipelines.

Basic Information

Product Name	[1-(2,2-Difluoroethyl)-3-Methyl-6-Oxo-4-(Trifluoromethyl)-1,6-Dihydro-7H-Pyrazolo[3,4-B]Pyridin-7-Yl]Acetic Acid
CAS No.	1018052-55-5
Molecular Formula	C₁₂H₉F₅N₂O₃
Molecular Weight	324.21 g/mol
Synonyms	1-(2,2-Difluoroethyl)-3-methyl-6-oxo-4-(trifluoromethyl)-1,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-ylacetic acid; 7H-Pyrazolo[3,4-b]pyridin-7-ylacetic acid, 1-(2,2-difluoroethyl)-1,6-dihydro-3-methyl-6-oxo-4-(trifluoromethyl)-; (1-(2,2-Difluoroethyl)-3-methyl-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrazolo[3,4-b]pyridin-7-yl)acetic acid; Difluoroethyl-methyl-oxo-trifluoromethyl-dihydropyrazolopyridinyl acetic acid; DFMOTPDPA; CAS 1018052-55-5.
EINECS	Contact for details

Quality Control

Our [1-(2,2-Difluoroethyl)-3-Methyl-6-Oxo-4-(Trifluoromethyl)-1,6-Dihydro-7H-Pyrazolo[3,4-B]Pyridin-7-Yl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.