Description

(5-Bromo-3-Pyridinyl)(Piperazino)Methanone is a high-purity organic building block featuring a brominated pyridine core linked to a piperazine moiety via a carbonyl group. This molecular architecture makes it a critical intermediate for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing targeted therapies, particularly in areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile bromine handle for further functionalization.
• Library Synthesis: A valuable building block for constructing diverse compound libraries via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and amide bond formations.
• Biochemical Probe Development: Employed in the design and synthesis of chemical probes for studying enzyme kinetics and receptor-ligand interactions in biological systems.
• Agrochemical Research: Potential intermediate in the development of new agrochemicals, such as herbicides or insecticides, leveraging its heterocyclic structure.

Basic Information

Product Name	(5-Bromo-3-Pyridinyl)(Piperazino)Methanone
CAS No.	1017782-91-0
Molecular Formula	C11H12BrN3O
Molecular Weight	282.14 g/mol
Synonyms	1-[(5-Bromo-3-pyridinyl)carbonyl]piperazine; (5-Bromo-3-pyridyl)(piperazin-1-yl)methanone; 5-Bromo-N-(piperazin-1-yl)nicotinamide; 5-Bromo-3-pyridinecarboxylic acid piperazide; 1017782-91-0; 5-Bromo-3-pyridinyl-piperazin-1-yl-methanone
EINECS	Contact for details

Quality Control

Our (5-Bromo-3-Pyridinyl)(Piperazino)Methanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with standards expected for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.