Description

n-Boc-3-Bromo-4-Hydroxy-Pyrrolidine CAS NO 1017782-17-0 is a high-purity, protected pyrrolidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex nitrogen-containing heterocycles, essential for developing novel active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of potential drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other biologically active molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry: Serves as a starting material or intermediate in the scalable production of target drug substances under GMP conditions.
• Peptidomimetics Development: Employed in the design and synthesis of peptidomimetic compounds that mimic the structure and function of natural peptides.
• Chemical Biology Probes: Useful for creating molecular probes to study enzyme function and biological pathways.
• Agrochemical Synthesis: Potential intermediate in the development of novel herbicides or fungicides with specific chiral centers.

Basic Information

Product Name	n-Boc-3-Bromo-4-Hydroxy-Pyrrolidine
CAS No.	1017782-17-0
Molecular Formula	C9H16BrNO3
Molecular Weight	266.13 g/mol
Synonyms	1-Boc-3-bromo-4-hydroxypyrrolidine; tert-Butyl 3-bromo-4-hydroxypyrrolidine-1-carboxylate; 3-Bromo-4-hydroxy-1-(tert-butoxycarbonyl)pyrrolidine; 1-(tert-Butoxycarbonyl)-3-bromo-4-hydroxypyrrolidine; 3-Bromo-4-hydroxy-N-Boc-pyrrolidine; 4-Hydroxy-3-bromo-1-Boc-pyrrolidine; Pyrrolidine, 3-bromo-4-hydroxy-1-[(1,1-dimethylethoxy)carbonyl]-; 1017782-17-0
EINECS	Contact for details

Quality Control

Our n-Boc-3-Bromo-4-Hydroxy-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.