Description

1-(6-Bromopyridin-2-Yl)-4-Hydroxypiperidine is a high-purity brominated piperidine derivative, a crucial advanced pharmaceutical intermediate (API intermediate) for modern drug discovery and development. Its molecular structure, featuring both a bromopyridine moiety and a hydroxypiperidine group, makes it a versatile building block for constructing complex bioactive molecules. This compound is primarily sought by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

This specialized intermediate serves as a key precursor in several high-value chemical synthesis pathways:

• Pharmaceutical Intermediate: Core building block for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new molecular entities.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Ligand and Catalyst Synthesis: Utilized in the preparation of complex ligands for catalysis or as a scaffold for metal-organic frameworks (MOFs).
• Agrochemical Research: Intermediate in the development of new crop protection agents and pesticides.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Details
Product Name	1-(6-Bromopyridin-2-Yl)-4-Hydroxypiperidine
CAS No.	1017781-64-4
Molecular Formula	C10H13BrN2O
Molecular Weight	257.13 g/mol
Synonyms	4-Hydroxy-1-(6-bromo-2-pyridinyl)piperidine; 1-(6-Bromo-2-pyridinyl)-4-hydroxypiperidine; 1-(6-Bromopyridin-2-yl)piperidin-4-ol; 4-Hydroxy-1-(6-bromopyridin-2-yl)piperidine; 6-Bromo-2-(4-hydroxypiperidin-1-yl)pyridine; (6-Bromo-2-pyridyl)-4-hydroxypiperidine; 1-(6-Bromo-2-pyridyl)-4-piperidinol; CAS 1017781-64-4
EINECS	Contact for details

Quality Control

Our 1-(6-Bromopyridin-2-Yl)-4-Hydroxypiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to standards suitable for research and non-GMP pharmaceutical applications, with the capability to discuss custom synthesis under controlled GMP-like conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.