Description

tert-Butyl 2-(4-Methoxybenzyl)-3-Oxospiro[Isoindoline-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of complex molecules, particularly those targeting central nervous system (CNS) disorders. It is primarily needed by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Drug Discovery Scaffold: Used as a core spirocyclic structure for constructing compound libraries in high-throughput screening (HTS) campaigns.
• Neurological Research: Employed in the synthesis of potential candidates for treating conditions such as depression, anxiety, and neurodegenerative diseases.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of synthetic routes for clinical trial material (CTM) and commercial API manufacturing.
• Academic Research: Utilized in universities and research institutes for studying structure-activity relationships (SAR) and novel synthetic methodologies.
• Custom Synthesis: Basis for the preparation of specialized derivatives and analogs for proprietary research programs.

Basic Information

Product Name	tert-Butyl 2-(4-Methoxybenzyl)-3-Oxospiro[Isoindoline-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1017540-78-1
Molecular Formula	C26H30N2O4
Molecular Weight	434.53 g/mol
Synonyms	1'-tert-Butoxycarbonyl-2-(4-methoxybenzyl)-3-oxospiro[isoindoline-1,4'-piperidine]; tert-Butyl 2-(4-methoxybenzyl)-3-oxo-1,4-dihydrospiro[isoindole-1,4'-piperidine]-1'-carboxylate; Spiro[isoindoline-1,4'-piperidine]-1'-carboxylic acid, 2-[(4-methoxyphenyl)methyl]-3-oxo-, 1,1-dimethylethyl ester; 1017540-78-1; BOC-protected spirocyclic isoindolinone; 2-(4-Methoxybenzyl)-3-oxospiro[isoindoline-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(4-Methoxybenzyl)-3-Oxospiro[Isoindoline-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.