Description

2-Methyl-3-(Pyridin-3-Yl)Propanoic Acid CAS NO 1017146-67-6 is a high-purity, non-natural amino acid derivative featuring a pyridine moiety, making it a valuable chiral building block for advanced organic synthesis. Its primary value lies in its role as a key intermediate in the research and development of novel pharmaceutical compounds, particularly in the creation of active pharmaceutical ingredients (APIs) and bioactive molecules. This product is essential for medicinal chemists, process R&D scientists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disorder research.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the manufacture of proprietary APIs under GMP conditions.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry is required for bioactivity.
• Ligand and Catalyst Preparation: Employed in the development of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics and Bio-conjugation: Acts as a non-proteinogenic amino acid analog for creating stable peptide mimics and bioconjugates in drug discovery.
• Academic and Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Item	Detail
Product Name	2-Methyl-3-(Pyridin-3-Yl)Propanoic Acid
CAS No.	1017146-67-6
Molecular Formula	C9H11NO2
Molecular Weight	165.19 g/mol
Synonyms	3-(3-Pyridyl)-2-methylpropanoic acid; 2-Methyl-3-(3-pyridyl)propionic acid; (R/S)-2-Methyl-3-(pyridin-3-yl)propanoic acid; β-Methyl-3-pyridinepropanoic acid; 3-Pyridinepropanoic acid, 2-methyl-; 1017146-67-6; 2-Methyl-3-(3-pyridinyl)propanoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-3-(Pyridin-3-Yl)Propanoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical R&D and GMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (HPLC), chiral purity, and impurity profiles. Our quality commitment aligns with ICH guidelines, and we can support custom specifications for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.