Description

tert-Butyl 2-Amino-1-(2,4-Difluorophenyl)Ethylcarbamate is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) where precise stereochemistry is paramount. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, especially within the fields of central nervous system (CNS) and anti-infective drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting neurological and infectious diseases.
• Peptidomimetic Research: Used to introduce fluorinated phenylalanine analogs into peptide chains to enhance metabolic stability and binding affinity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct stereogenic centers.
• Protease Inhibitor Development: Serves as a core structural element in the design and synthesis of novel protease enzyme inhibitors.
• Chemical Biology Probes: Utilized in the creation of fluorinated chemical probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects under cGMP guidelines.

Basic Information

Product Name	tert-Butyl 2-Amino-1-(2,4-Difluorophenyl)Ethylcarbamate
CAS No.	1016680-39-9
Molecular Formula	C13H18F2N2O2
Molecular Weight	272.29 g/mol
Synonyms	1-(2,4-Difluorophenyl)-2-[(tert-butoxycarbonyl)amino]ethane; Boc-2,4-Difluoro-DL-phenylalaninol; tert-Butyl N-[1-(2,4-difluorophenyl)-2-hydroxyethyl]carbamate (related alcohol); 2-Amino-1-(2,4-difluorophenyl)ethyl carbamic acid tert-butyl ester; Boc-2,4-Difluoro-Phe-ol; N-Boc-1-(2,4-difluorophenyl)ethan-1-amine-2-ol; (±)-1-(2,4-Difluorophenyl)-2-[(tert-butoxycarbonyl)amino]ethanol
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Amino-1-(2,4-Difluorophenyl)Ethylcarbamate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can supply material suitable for use under cGMP conditions for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomerically enriched grade available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.