Description

5-Amino-1-[(2-Chlorophenyl)Methyl]-1,2-Dihydropyridin-2-One is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a critical building block for the development of next-generation antiviral and antiretroviral active pharmaceutical ingredients (APIs). This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of treatments for viral infections, requiring a reliable supply of high-quality, well-characterized chemical intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs.
• Antiviral Drug Development: Used in research and production of novel antiviral agents targeting specific viral enzymes.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core building block in multi-step synthetic routes for final API molecules.
• Biochemical Research: Employed in biochemical assays and studies to understand enzyme inhibition mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.
• Process Chemistry & Optimization: Used by process chemists to develop scalable, efficient, and cost-effective manufacturing routes.

Basic Information

Product Name	5-Amino-1-[(2-Chlorophenyl)Methyl]-1,2-Dihydropyridin-2-One
CAS No.	1016527-33-5
Molecular Formula	C12H11ClN2O
Molecular Weight	234.68 g/mol
Synonyms	5-Amino-1-(2-chlorobenzyl)pyridin-2(1H)-one; 1-(2-Chlorobenzyl)-5-amino-1,2-dihydropyridin-2-one; 5-Amino-1-(2-chlorobenzyl)-1,2-dihydro-2-pyridinone; NNRTI Intermediate; 2(1H)-Pyridinone, 5-amino-1-[(2-chlorophenyl)methyl]-
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-1-[(2-Chlorophenyl)Methyl]-1,2-Dihydropyridin-2-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.