Description

1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Fluoro- is a high-value fluorinated heterocyclic building block essential for modern pharmaceutical and agrochemical research. Its core value lies in its unique pyrrolopyridine scaffold, which serves as a privileged structure for modulating biological activity and pharmacokinetic properties in drug discovery. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and candidates for oncology, CNS, and anti-infective therapies.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated pyrrolopyridine core.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials and ligands for catalytic systems.
• Chemical Biology Probe Development: Utilized in creating fluorescent tags or molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex molecules.
• Academic & Contract Research: A critical reagent for synthetic methodology development and exploration of new chemical space in academic and CRO settings.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Fluoro-
CAS No.	1016241-78-3
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	3-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 3-Fluoro-2-carboxy-1H-pyrrolo[2,3-b]pyridine; 3-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 3-Fluoropyrrolo[2,3-b]pyridine-2-carboxylic acid; 3-Fluoro-7-azaindole-2-carboxylic acid; 3-Fluoro-1H-7-azaindole-2-carboxylic acid; 3-Fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 3-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.