Description

4-(1-Chloroethyl)-3-Fluoro-Pyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. This compound is valued for its unique molecular architecture, which enables precise structural modifications in complex molecule assembly. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and chlorine substituents for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel pyridine-based ligands used in transition metal catalysis for fine chemical and polymer production.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and functional polymers due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	4-(1-Chloroethyl)-3-Fluoro-Pyridine
CAS No.	1016228-83-3
Molecular Formula	C7H7ClFN
Molecular Weight	159.59 g/mol
Synonyms	3-Fluoro-4-(1-chloroethyl)pyridine; 4-(1-Chloroethyl)-3-fluoropyridine; 3-Fluoro-4-(α-chloroethyl)pyridine; 1-(3-Fluoropyridin-4-yl)ethyl chloride; 4-(α-Chloroethyl)-3-fluoropyridine; Pyridine, 4-(1-chloroethyl)-3-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 4-(1-Chloroethyl)-3-Fluoro-Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.