Description

1-(6-Bromo-3-Fluoro-Pyridin-2-Yl)-Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its distinct bromo-fluoro pyridine core structure. This compound is essential for medicinal chemists and process development teams engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by R&D and manufacturing organizations in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to incorporate a halogenated heterocyclic building block with high reactivity and selectivity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine moiety.
• Material Science Research: Serves as a precursor for creating functionalized ligands and organic electronic materials.
• Cross-Coupling Reactions: An ideal substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for generating diverse compound libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated intermediates.

Basic Information

Product Name	1-(6-Bromo-3-Fluoro-Pyridin-2-Yl)-Ethanone
CAS No.	1016228-01-5
Molecular Formula	C7H5BrFNO
Molecular Weight	218.03 g/mol
Synonyms	2-Acetyl-6-bromo-3-fluoropyridine; 6-Bromo-3-fluoro-2-acetylpyridine; Ethanone, 1-(6-bromo-3-fluoro-2-pyridinyl)-; 1-(6-Bromo-3-fluoropyridin-2-yl)ethan-1-one; 2-Acetyl-3-fluoro-6-bromopyridine; 3-Fluoro-6-bromo-2-acetylpyridine; 1-(6-Bromo-3-fluoropyridin-2-yl)ethanone
EINECS	Contact for details

Quality Control

Our 1-(6-Bromo-3-Fluoro-Pyridin-2-Yl)-Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.