Description

2-Benzyl-8-Chloro-1,2,3,4-Tetrahydrobenzo[B][1,6]Naphthyridine-10-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential therapeutic agents, particularly those targeting central nervous system (CNS) disorders.
• Drug Discovery Research: Used as a scaffold or building block in medicinal chemistry for creating compound libraries and exploring structure-activity relationships (SAR).
• API Development: Integral in the process development and scale-up of new chemical entities (NCEs) for clinical trials.
• Biochemical Research: May be utilized as a tool compound or inhibitor in biochemical assays to study specific enzymatic pathways or receptor interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2-Benzyl-8-Chloro-1,2,3,4-Tetrahydrobenzo[B][1,6]Naphthyridine-10-Carboxylic Acid
CAS No.	1015856-16-2
Molecular Formula	C24H21ClN2O2
Molecular Weight	404.89 g/mol
Synonyms	8-Chloro-2-benzyl-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-10-carboxylic acid; 2-Benzyl-8-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-10-carboxylic acid; Benzo[b][1,6]naphthyridine-10-carboxylic acid, 2-benzyl-8-chloro-1,2,3,4-tetrahydro-; 1015856-16-2; BCNT-10-COOH; 8-Cl-Bz-THBNC
EINECS	Contact for details

Quality Control

Our production of 2-Benzyl-8-Chloro-1,2,3,4-Tetrahydrobenzo[B][1,6]Naphthyridine-10-Carboxylic Acid adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment. We support development and commercial projects with material produced under quality agreements and can supply material suitable for use under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.