Description

1,8-Dioxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid is a high-value spirocyclic heterocyclic building block featuring a fused oxazine and carboxylic acid functionality. This compound matters as a versatile synthon for constructing complex molecular architectures in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and life science industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug discovery programs.
• Medicinal Chemistry Scaffold: Used to create spirocyclic compound libraries for high-throughput screening (HTS) to identify new lead structures with improved biological activity and pharmacokinetic properties.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Ligand and Catalyst Development: The spirocyclic structure and heteroatoms make it a candidate for developing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probe: Utilized to design and synthesize molecular probes for studying enzyme function and biological pathways.

Basic Information

Item	Detail
Product Name	1,8-Dioxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid
CAS No.	1015770-89-4
Molecular Formula	C8H11NO4
Molecular Weight	185.18 g/mol
Synonyms	1,8-Dioxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid; 2-Azaspiro[4.5]dec-2-ene-3-carboxylic acid, 1,8-dioxa-; 3-Carboxy-1,8-dioxa-2-azaspiro[4.5]dec-2-ene; Spiro[1,3-oxazine-4,1'-cyclopentane]-2-carboxylic acid, 5,6-dihydro-; (1,8-Dioxa-2-azaspiro[4.5]dec-2-en-3-yl)carboxylic acid
EINECS	Contact for details

Quality Control

Our 1,8-Dioxa-2-azaspiro[4.5]dec-2-ene-3-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.