Description

4-Chloro-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine is a high-value halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular scaffold, featuring both chloro and iodo substituents, makes it a versatile intermediate for constructing complex pharmacophores. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyrrolopyridine core.
• Material Science: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology: Employed as a molecular probe or a tagging reagent in bioconjugation chemistry and proteomics research.
• Cross-Coupling Reactions: The iodo and chloro groups are excellent handles for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings, enabling rapid diversification.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	4-Chloro-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1015610-31-7
Molecular Formula	C7H4ClIN2
Molecular Weight	278.48 g/mol
Synonyms	4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-iodo-; 4-Chloro-5-iodo-7-azaindole; 5-Iodo-4-chloro-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-iodo-7-aza-indole; 4-Chloro-5-iodo-1H-7-azaindole; 4-Cl-5-I-7-azaindole; 4-Chloro-5-iodo-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Iodo-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for research and development. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry. A Certificate of Analysis (COA) is supplied with each batch to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.