Description

4-Chloro-5-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functionalized heterocyclic building block designed for advanced organic synthesis. This compound is critical for medicinal chemistry research and development, serving as a key intermediate in the construction of complex molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for the synthesis of novel drug candidates, particularly in kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule therapeutics, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study biological pathways and protein function.
• Agrochemical Synthesis: Potential intermediate in the development of new active ingredients for crop protection.
• Material Science: Can be incorporated into advanced organic electronic materials due to its fused heterocyclic structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	4-Chloro-5-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1015609-83-2
Molecular Formula	C16H22ClIN2Si
Molecular Weight	432.80 g/mol
Synonyms	1-(Triisopropylsilyl)-4-chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS-4-Chloro-5-Iodo-pyrrolopyridine; 4-Cl-5-I-1-TIPS-1H-Pyrrolo[2,3-b]pyridine; 1015609-83-2; 4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine, 1-(triisopropylsilyl)-; Pyrrolo[2,3-b]pyridine, 4-chloro-5-iodo-1-(triisopropylsilyl)-1H-
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Iodo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.