Description

6-Bromo-1-(Triisopropylsilyl)-1H-Pyrrolo[3,2-B]Pyridine is a high-value, organosilicon-protected heterocyclic building block, specifically designed for advanced synthetic chemistry. Its core value lies in enabling precise molecular construction in complex pharmaceutical and agrochemical research, where protecting group strategies are critical. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, particularly in the fields of oncology, CNS disorders, and crop protection.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Protecting Group Strategy: The triisopropylsilyl (TIPS) group protects the pyrrole nitrogen, allowing for selective functionalization at other positions on the heterocyclic core.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	6-Bromo-1-(Triisopropylsilyl)-1H-Pyrrolo[3,2-B]Pyridine
CAS No.	1015609-27-4
Molecular Formula	C17H27BrN2Si
Molecular Weight	367.40 g/mol
Synonyms	6-Bromo-1-(triisopropylsilyl)-1H-pyrrolo[3,2-b]pyridine; 1H-Pyrrolo[3,2-b]pyridine, 6-bromo-1-(triisopropylsilyl)-; 6-Bromo-1-TIPS-1H-pyrrolo[3,2-b]pyridine; TIPS-Protected 6-Bromopyrrolopyridine; 6-Bromo-1-(triisopropylsilyl)-7-azaindole (common name based on structure); 1015609-27-4; 6-Br-1-TIPS-pyrrolo[3,2-b]pyridine
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-1-(Triisopropylsilyl)-1H-Pyrrolo[3,2-B]Pyridine undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for advanced research and development. Our quality assurance protocols are designed to support cGMP and ISO standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment to guarantee supply reliability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.