Description

2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-8-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable supply of high-quality building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic entities.
• Alkaloid Synthesis: Acts as a precursor in the synthesis of complex indole and tetrahydro-β-carboline alkaloid analogs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in the study of enzyme inhibitors and receptor ligands due to its specific molecular scaffold.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-8-Carboxylic Acid Methyl Ester
CAS No.	1015082-04-8
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	Methyl 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylate; 8-Methoxycarbonyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; Tetrahydro-β-carboline-8-carboxylic acid methyl ester; 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-9-carboxylic acid, methyl ester (alternative numbering); 1015082-04-8; Pyridoindole methyl ester intermediate.
EINECS	Contact for details

Quality Control

Our 2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole-8-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.