Description

Benzenesulfonic Acid, 4-Nitro-, [(2S,4R)-4-(3-Chloropropyl)-5-Oxo-2-Pyrrolidinyl]Methyl Ester is a high-purity, non-racemic chiral building block and synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring a pyrrolidinone core, a chloropropyl linker, and a nitrobenzenesulfonate ester group, makes it a versatile precursor for constructing sophisticated active pharmaceutical ingredients (APIs). This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents, particularly those targeting the central nervous system and other specialized applications.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Protease Inhibitor Synthesis: The pyrrolidinone scaffold is a common motif in inhibitors for various enzymes, making this ester a potential precursor.
• Peptidomimetic Development: Used to create novel peptide-like compounds with enhanced stability and bioavailability for drug discovery.
• Chemical Biology Probes: Can be utilized to develop tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	Benzenesulfonic Acid, 4-Nitro-, [(2S,4R)-4-(3-Chloropropyl)-5-Oxo-2-Pyrrolidinyl]Methyl Ester
CAS No.	1013937-94-4
Molecular Formula	C15H19ClN2O6S
Molecular Weight	390.84 g/mol
Synonyms	(2S,4R)-4-(3-Chloropropyl)-5-oxo-2-pyrrolidinylmethyl 4-nitrobenzenesulfonate; 4-Nitrobenzenesulfonic Acid (2S,4R)-4-(3-Chloropropyl)-5-oxo-2-pyrrolidinylmethyl Ester; 4-Nitrobenzenesulfonyl Chloride (2S,4R)-4-(3-Chloropropyl)-5-oxo-2-pyrrolidinylmethyl Ester Derivative; (4R)-4-(3-Chloropropyl)-2-[[(4-nitrophenyl)sulfonyl]oxy]methyl]-5-pyrrolidinone; Chiral Pyrrolidinone Sulfonate Ester; 1013937-94-4; 4-NO2-Bs Ester of (2S,4R)-4-(3-Chloropropyl)-5-oxo-2-pyrrolidinylmethanol
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and purity essential for pharmaceutical research. Our products undergo rigorous analytical testing, including HPLC, chiral HPLC, NMR, and mass spectrometry, to confirm identity, enantiomeric excess, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and regulatory filings with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its complex organic ester structure, it should be stored separately from strong acids, bases, and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.