Description

4-Piperidinecarbonitrile, 3-Hydroxy-1-(Phenylmethyl)-, (3R,4R)-Rel- is a chiral piperidine derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel pharmaceutical actives, particularly in the areas of central nervous system (CNS) agents and enzyme inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of enantiomerically pure drugs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of potential drug candidates targeting neurological disorders.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Can be incorporated into molecules designed to study biological pathways and enzyme functions.

Basic Information

Product Name	4-Piperidinecarbonitrile, 3-Hydroxy-1-(Phenylmethyl)-, (3R,4R)-Rel-
CAS No.	1013333-20-4
Molecular Formula	C13H16N2O
Molecular Weight	216.28 g/mol
Synonyms	(3R,4R)-3-Hydroxy-1-benzylpiperidine-4-carbonitrile; rel-(3R,4R)-1-Benzyl-3-hydroxypiperidine-4-carbonitrile; 1-Benzyl-3-hydroxypiperidine-4-carbonitrile (rel-(3R,4R)-); (R,R)-1-Benzyl-3-hydroxypiperidine-4-carbonitrile (relative configuration); 4-Cyano-1-benzyl-3-hydroxypiperidine; 3-Hydroxy-1-benzyl-4-piperidinecarbonitrile
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request. Our quality system supports development under cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.