Description

2-Bromo-5-Triethylsilylpyridine is a high-value organosilicon-protected pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic combination of a bromo substituent for cross-coupling reactions and a robust triethylsilyl protecting group, offering superior stability and selectivity. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require precise intermediates for constructing complex heterocyclic architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the pyridine core is a common bioactive motif.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis, such as Suzuki-Miyaura and Buchwald-Hartwig cross-couplings.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its functionalized aromatic system.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological processes and protein interactions.
• Custom Synthesis and Scale-up: A versatile substrate for contract research organizations (CROs) and custom synthesis providers working on multi-step synthetic routes.

Basic Information

Product Name	2-Bromo-5-Triethylsilylpyridine
CAS No.	1012314-95-2
Molecular Formula	C13H22BrNSi
Molecular Weight	300.31 g/mol
Synonyms	5-(Triethylsilyl)-2-bromopyridine; 2-Bromo-5-(triethylsilyl)pyridine; Pyridine, 2-bromo-5-(triethylsilyl)-; 2-Bromo-5-triethylsilyl pyridine; 2-Bromo-5-(triethylsilyl)pyridine; 1012314-95-2; 2-Br-5-TES-pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Triethylsilylpyridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.