Description

1H-Benzimidazole-5-Carboxylic Acid, 2-Amino-1-[trans-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclohexyl]-, Ethyl Ester is a sophisticated, multi-functional organic intermediate featuring a benzimidazole core protected by a tert-butyldimethylsilyl (TBDMS) group. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, offering chemists precise control over molecular architecture. It is primarily needed by pharmaceutical and biotechnology R&D teams focused on developing new therapeutic agents, particularly in areas requiring advanced heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially those targeting protein kinases and other enzymatic pathways.
• Protease Inhibitor Research: Used in the development and optimization of protease inhibitors, a crucial class of drugs for virology and oncology.
• Chemical Biology Probes: Employed in the creation of labeled or tagged molecules for studying biological processes and target engagement.
• Peptidomimetic Synthesis: Acts as a constrained scaffold to mimic peptide structures, enhancing metabolic stability and bioavailability in drug design.
• Agrochemical Development: Utilized in research for creating new active ingredients with specific modes of action.
• Material Science: Potential application in the synthesis of specialty polymers or organic electronic materials due to its conjugated benzimidazole system.

Basic Information

Product Name	1H-Benzimidazole-5-Carboxylic Acid, 2-Amino-1-[trans-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclohexyl]-, Ethyl Ester
CAS No.	1012104-43-6
Molecular Formula	C22H35N3O3Si
Molecular Weight	417.63 g/mol
Synonyms	Ethyl 2-amino-1-(trans-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-1H-benzimidazole-5-carboxylate; 2-Amino-1-[trans-4-[(tert-butyldimethylsilyl)oxy]cyclohexyl]-1H-benzimidazole-5-carboxylic acid ethyl ester; TBDMS-protected benzimidazole ester; 1H-Benzimidazole-5-carboxylic acid, 2-amino-1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-, ethyl ester, trans-; 1012104-43-6; tert-Butyldimethylsilyl-protected amino benzimidazole carboxylate
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole-5-Carboxylic Acid, 2-Amino-1-[trans-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclohexyl]-, Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is between 2°C and 8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.